Description
Our hero product. A K-beauty cult classic that soothes redness, repairs post-blemish skin, and strengthens the barrier β with 3 soothing, 4 nourishing, and 5 relief-focused ingredient groups (hence the 345). If you buy one thing from us, buy this.
THE STORY
Every skin has a season where it just won’t cooperate β a breakout that lingers, a new active that leaves your face tight and pink, a stretch of weather that strips your barrier bare. Dr.Althea built the 345 Relief Cream specifically for that season. It’s less a “moisturizer” in the traditional sense and more a recovery formula: something you reach for when skin needs to calm down and rebuild before it can handle anything else.
The “345” naming isn’t marketing fluff β it genuinely maps to three functional ingredient groups packed into one gel-cream texture: three blemish-relief actives, four nourishing barrier-support ingredients, and five soothing botanicals. That structure is why it reads as multi-purpose rather than single-note; it’s doing repair, hydration, and calming work all at once, in one step.
KEY INGREDIENTS AND HOW THEY WORK
At the barrier-repair core sits Ceramide NP, one of the lipids your skin already produces naturally to hold its outer layer together. When a barrier is compromised β from over-exfoliation, harsh weather, or active breakouts β it loses ceramides faster than it can replace them, which is exactly when skin starts to feel tight, flaky, or reactive. Replacing that lipid topically helps the skin’s own “mortar” reform faster.
Alongside it is Sodium DNA, derived from rice bran and often referred to as a form of PDRN (polydeoxyribonucleotide) β an ingredient that’s become a mainstay in Korean regenerative skincare for its role in supporting skin repair and renewal. Resveratrol, a polyphenol antioxidant, adds a layer of protection against the everyday oxidative stress from pollution and blue light that can slow healing down.
On the calming side, the formula leans on Centella Asiatica Leaf Water and Madecassoside (one of centella’s most studied active compounds), both long used in Korean skincare to visibly reduce redness and support skin already dealing with irritation. Tea Tree Leaf Water contributes a gentle antibacterial, clarifying note without the harshness of tea tree oil itself, which pairs naturally with post-blemish skin. Niacinamide rounds it out, helping even visible tone as marks and redness fade, and supporting the same barrier the ceramide is working to rebuild.
WHO IT’S FOR
This cream was designed with reactive, post-acne, and sensitized skin in mind first β but its non-comedogenic, fragrance-conscious, vegan formula makes it broadly wearable across skin types. If your skin is currently dealing with active breakouts, post-inflammatory redness, a compromised barrier from retinoids or acids, or just a general “my skin doesn’t feel like mine right now” phase, this is built for exactly that moment. It’s also gentle enough to become a permanent last step for anyone who simply wants steady, low-drama hydration.
HOW TO USE
Apply as the final step of your routine, morning and/or night, after any serums or treatments have fully absorbed. Warm a small amount between your fingertips first, then press β rather than rub β it into the skin, working outward from the center of the face. Pressing (instead of dragging) helps the product settle into the skin without disturbing any actively healing areas. A little goes further than you’d expect; most people find a pea-to-almond-sized amount covers the full face and neck.
For skin that’s mid-breakout or freshly post-procedure (after an extraction, a peel, or a new retinoid), this can also be layered as a spot-recovery step: a slightly thicker layer directly over the area, left on overnight.
PAIRING IT INTO YOUR ROUTINE
It plays especially well after our Hyalu B5 Hyaluronic Serum, which delivers the water this cream then locks in, and it’s gentle enough to follow a night using the Paula’s Choice 2% BHA Exfoliant, when skin needs extra calming the morning after.
THE DETAILS
Size: 1.69 oz. Texture: lightweight gel-cream. Skin type: all, including sensitive and post-blemish. Free from common heavy oils and unnecessary fragrance load; formulated as vegan and non-comedogenic.





Maya R. (verified owner) –
This calmed my post-breakout redness faster than anything else I’ve tried. A little goes a long way.
Priya K. (verified owner) –
My skin barrier finally feels normal again. Repurchasing for sure.